Project Details
Projekt
Adenine nucleotide-modulated T cell differentiation and effector functions (A03)
Subject Area
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
Nicotinic acid adenine dinucleotide phosphate (NAADP) modulates T cell receptor-induced Ca²⁺ signaling and shapes CD4⁺ and CD8⁺ T cell responses via two pore channels (TPC) 1 and 2. However, the underlying mechanisms and the role of the NAADP binding protein Jupiter microtubule-associated homolog 2 (JPT2) in these processes remain unclear. To clarify the function of these proteins in NAADP signaling, we will use pharmacological approaches to analyze mouse and human T cells in vitro. Studies will be complemented with analyses of mice deficient in TPC1, TPC2 or JPT2 in infection and intestinal inflammation models in vivo.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Dr. Samuel Huber; Professor Dr. Hans-Willi Mittrücker
