Project Details
Projekt
Controlling T cell response by cAMP signaling (A06)
Subject Area
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
3’,5’-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger with a pivotal role in immunomodulation. The formation and degradation of intracellular cAMP is regulated by diverse pathways. We will explore phosphodiesterase (PDE) 2A and natriuretic peptides (NP) and investigate how they mechanistically impact T cell function and contribute to neuroinflammation by modulating cAMP. Together with an unsupervised approach to discover GPCR(s) that control T cell activity, our research will provide an understanding of the molecular mechanisms that control cAMP levels in T cells that can potentially be exploited therapeutically.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Dr. Manuel A. Friese; Professor Dr. Viacheslav Nikolaev
