Project Details
Projekt
Controlling T cell response by cAMP signaling (A06)
Subject Area
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
3’,5’-Cyclic adenosine monophosphate (cAMP) is a second messenger with a pivotal role in immunomodulation. The formation and degradation of intracellular cAMP is regulated by diverse pathways. During the 1st and the 2nd funding period we have identified phosphodiesterase (PDE) 2A and C-type natriuretic peptide (CNP) upregulation in activated mouse T-cells and neurons, respectively, which can critically contribute to neuroinflammation. We will now investigate how these pathways impact T cell function and neuroinflammation by modulating cAMP in mouse and human cells. PDE2 inhibition and CNP modulation will be tested as potential pharmacological targets.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Dr. Manuel A. Friese; Professor Dr. Viacheslav Nikolaev
