Project Details
Projekt
Glial cAMP and Ca2+ signaling in two models of neuroinflammation (A07)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
We will investigate cAMP and Ca2+ signaling in astrocytes and microglial cells during neuroinflammation, using experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis and middle cerebral artery occlusion (MCAO) as a stroke model. By imaging cAMP and Ca2+ signals with genetically encoded indicators, we aim to characterize receptor-mediated cAMP and Ca2+ signaling in spinal cord astrocytes and microglial cells in both healthy and EAE mice. Additionally, using the photoactivatable adenylate cyclase PACmn, we will examine how increased cAMP affects glial physiology and the glial-dependent regulation of EAE in spinal cord and MCAO in cortex.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Christine Elizabeth Gee, Ph.D.; Professor Dr. Christian Lohr
