Project Details
Projekt
The role of cAMP at the blood-brain barrier in stroke (A13)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
Purinergic signaling plays a crucial role in modulating the post-ischemic inflammatory response in stroke. In the last funding period, we observed protective effects of attenuated extracellular ATP signaling in stroke, and we now seek to understand how purinergic signaling at the BBB influences intracellular signaling pathways. Specifically, we hypothesize that the effects of extracellular adenine nucleotides at the BBB are linked to modulation of intracellular cAMP signaling. Using advanced imaging techniques and transgenic mouse models, we will investigate the spatio-temporal dynamics of cAMP signaling at the murine BBB during stroke.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Privatdozent Dr. Jakob Körbelin, since 7/2022; Professor Dr. Tim Magnus; Professorin Dr. Eva Tolosa, Ph.D., until 6/2022
