Project Details
Projekt
Dissecting the role of ATP and adenosine receptor signaling for immune adaptation of intestinal Th17 cells (A14)
Subject Area
Immunology
Term
since 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
The ability of effector T helper cells to switch from a pro- to an anti-inflammatory function, i.e. immune adaptation, is fundamental for intestinal homeostasis. We hypothesize that immune adaptation in the intestine is controlled by the availability of ATP and adenosine (ADO) in the intestinal environment. In this second period we will address (i) the consequences of ATP sensing by intestinal Th17 cells, (ii) the role of cell- and extracellular vesicle-associated purinergic enzymes in the ATP to ADO degradation in the intestine, (iii) the consequences of the loss of adenosine A2A receptor signaling in Th17 cells, and (iv) the molecular mechanisms regulating the expression of CD73 and A2A receptors in Th17 cells.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Professor Nicola Gagliani, Ph.D.; Professorin Dr. Eva Tolosa
