Project Details
Projekt Print View

Purinergic modulation in inflammation-induced neurodegeneration (A16)

Subject Area Molecular and Cellular Neurology and Neuropathology
Term since 2018
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
 
Multiple sclerosis (MS) is the most frequent inflammatory disease of the central nervous system (CNS) also resulting in olfactory deficits. However, underlying mechanisms are not understood. The adenine nucleotide axis has a crucial role in regulation of neuro-glia communication and inflammation and thereby qualifies as an attractive switchboard for both. Using the EAE inflammation model we aim to profile the cellular vulnerability and molecular determinants of neurodegeneration in the olfactory bulb and to elucidate the role of the P2Y1R and related P2 receptors in astrocyte-neuron interaction under homeostatic and inflammatory conditions and test their neuroprotective therapeutic potential.
DFG Programme Collaborative Research Centres
Applicant Institution Universität Hamburg
 
 

Additional Information

Textvergrößerung und Kontrastanpassung