Project Details
Projekt Print View

Hybridization kinetics and non-equilibrium dynamics of random pools of oligonucleotides (P15)

Subject Area Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
Term from 2018 to 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 364653263
 
We will study, both experimentally and theoretically, hybridization kinetics within oligonucleotide pools and investigate how the composition of the pool – single-strands, partially hybridized, non-cognate complexes, and “perfectly matched” complexes – changes over time. As hybridization is strongly dependent on environmental parameters such as salt concentration and pH, we will then study the spatiotemporal dynamics of the sequence pools within salt gradients. We will develop experimental methods to monitor different species within the pool at different locations, and theoretical tools to analyze these complex dynamics.
DFG Programme CRC/Transregios
 
 

Additional Information

Textvergrößerung und Kontrastanpassung