Multifunctional liposomal containers based on polymeric microgels
Final Report Abstract
The project aimed to design and develop nanoconjugates consisting of a microgel and bilayer lipid vesicles (liposomes). Electrostatic adsorption of liposomes on the surface of microgel particles resulted in formation of multi-liposomal carriers (nanoconjugates) with increased stability against aggregation in biological environment. The liposomes were used to encapsulate biologically active substances which allowed increasing the useful capacity of the nanoconjugates and preparing the nanoconjugates with a controlled content of encapsulated substances. An increase in temperature induced a collapse of the microgels and squeezing of the liposome shell, followed by liposome disruption and a release of encapsulated drug molecules. The project was based on a multidisciplinary approach combining experimental methods available to research groups at the Lomonosov Moscow State University (Russia) and RWTH Aachen University (Germany) as, e.g. optical spectroscopy and microscopy, dynamic light scattering, as well as static scattering techniques.
Publications
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Electrostatic complexes between thermosensitive cationic microgels and anionic liposomes: Formation and triggered release of encapsulated enzyme. European Polymer Journal, 119, 222-228.
Panova, Tatiana V.; Kostenko, Stepan N.; Efimova, Anna A.; Evtushenko, Evgeniy G.; Plamper, Felix; Richtering, Walter; Yaropolov, Alexander I. & Yaroslavov, Alexander A.
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On the mechanism of payload release from liposomes bound to temperature-sensitive microgel particles. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 570, 396-402.
Ivashkov, Oleg V.; Yakimova, Tamara M.; Evtushenko, Evgeniy G.; Gelissen, Arjan P.H.; Plamper, Felix A.; Richtering, Walter & Yaroslavov, Alexander A.
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Temperature-induced unloading of liposomes bound to microgels. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 630, 127590.
Panova, Irina G.; Sudareva, Ekaterina A.; Novoskoltseva, Olga A.; Spiridonov, Vasiliy V.; Shtilman, Mikhail I.; Richtering, Walter & Yaroslavov, Alexander A.
