Structural and functional properties of meprin metalloproteases with regard to cell signaling (A13*)

• Subject Area: Biochemistry
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

The project deals with meprin proteases and their role as shedding enzymes. The amyloid precursor protein, the IL-6 receptor and the β1 integrin are cleaved differentially by meprin α and meprin β. Since meprin α and meprin β exhibit similar cleavage specificities, but do not share all substrates, the existence of exosites must be involved in substrate recognition. The project will identify and target exosites within meprin α and meprin β and analyze functional consequences of meprin β overexpression in vivo with regard to β1 integrin signaling.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Privatdozent Dr. Philipp Arnold