Project Details
Projekt
The role of lysosomal cathepsins in α-synuclein metabolism and Parkinson’s disease (B11*)
Subject Area
Biochemistry
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785
The project deals with the role of lysosomal proteases in Parkinson’s disease, which is characterized by conversion of α-synuclein from a soluble synaptic protein into insoluble amyloid fibrils accompanied by degeneration of dopaminergic neurons. The interplay of α-synuclein with lysosomal cathepsins D, B and L, involved in lysosomal degradation of α-synuclein, will be studied. Using iPS cell derived dopaminergic neurons, patient mutations in cathepsins will be examined, and cathepsins D, B and L will be analyzed as therapeutic targets in Parkinson’s disease.
DFG Programme
Collaborative Research Centres
Applicant Institution
Christian-Albrechts-Universität zu Kiel
Project Head
Professorin Dr. Friederike Zunke
