Project Details
Projekt
Regulation of matrix metalloprotease activity during proteolytic invasion of human macrophages (B13*)
Subject Area
Cell Biology
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785
The project studies the role of matrix metalloproteases (MMPs) in the proteolytic invasion of macrophages. Within cells, MMPs travel bidirectionally along microtubules, regulated by specific kinesin and dynein motor proteins and members of the RabGTPase family. A novel kinesin regulator of MMP-dependent extracellular matrix proteolysis was discovered. The role of this kinesin in the recycling pathways of MT1-MMP will be studied. Inhibitory peptides are developed and tested for modulation of macrophage invasion in a pathophysiologically relevant context.
DFG Programme
Collaborative Research Centres
Applicant Institution
Christian-Albrechts-Universität zu Kiel
Project Head
Professor Dr. Stefan Linder
