Rolle des Orphanrezeptors GPR55 in der Immunzellhomöostase und Atherosklerose
Zusammenfassung der Projektergebnisse
Immune mechanisms are crucially involved in the pathogenesis of atherosclerosis and its clinical manifestations. Mounting evidence demonstrates a role of B cells and humoral immunity in atherosclerotic cardiovascular disease, which is supported by elevated titers of disease-specific antibodies (against antigens derived from modified lipoproteins, such as oxidation-specific epitopes). B cells mediate both protective and detrimental effects in cardiovascular disease, as they can secrete antibodies with both pro-atherogenic and anti-atherogenic effects. Current research efforts aim to gain an improved understanding of how B cells influence atherosclerotic disease, with the ultimate goal to develop novel B cell-targeted therapies for this life-threatening disease. In this context, we studied the immunomodulatory role of GPR55, a G-protein coupled receptor that is activated by endogenous lipid mediators. Our findings in experimental mouse models of atherosclerosis and human plaques indicate that GRP55 signaling is important for limiting B cell activation and humoral responses during hypercholesterolemia, suggesting that GPR55 signaling has an atheroprotective role.
Projektbezogene Publikationen (Auswahl)
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Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications. Thrombosis and Haemostasis, 119(04), 567-575.
Guillamat-Prats, Raquel; Rami, Martina; Herzig, Stephan & Steffens, Sabine
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Immunotherapy for cardiovascular disease. European Heart Journal, 40(48), 3937-3946.
Lutgens, Esther; Atzler, Dorothee; Döring, Yvonne; Duchene, Johan; Steffens, Sabine & Weber, Christian
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GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation. Nature Cardiovascular Research, 1(11), 1056-1071.
Guillamat-Prats, Raquel; Hering, Daniel; Derle, Abhishek; Rami, Martina; Härdtner, Carmen; Santovito, Donato; Rinne, Petteri; Bindila, Laura; Hristov, Michael; Pagano, Sabrina; Vuilleumier, Nicolas; Schmid, Sofie; Janjic, Aleksandar; Enard, Wolfgang; Weber, Christian; Maegdefessel, Lars; Faussner, Alexander; Hilgendorf, Ingo & Steffens, Sabine
