Project Details
Projekt
HSCs under acute and chronic inflammatory stress (B13*)
Subject Area
Hematology, Oncology
Term
from 2018 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522
During inflammatory stress, quiescent hematopoietic stem cells (HSCs) are forced into transient proliferation, presumably to regenerate mature blood cells lost during the response. Many open questions remain as to how different inflammatory stimuli impact on the quiescence of HSCs, whether common or distinct mechanisms are involved in the HSC response and what the long-term consequences of stress-induced proliferation are on the function and behaviour of these HSCs. Here, we propose to combine a range of different inflammatory stimuli with loss of function mouse models to interrogate in more detail the mechanisms and short-term and long-term consequences of inflammation-induced activation of quiescent HSCs in vivo. This will allow us to elucidate whether such forms of environmental challenge, have the capacity to impact on HSC function in either a uniform or divergent manner.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Heads
Dr. Marieke Essers; Dr. Michael Milsom
