Signal Transduction and Function of cGMP/cGMP-dependent Protein Kinase Isozymes.

• Applicant: Professor Dr. Franz Hofmann
• Subject Area: Pharmacology
• Term: from 2007 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 40833648

• Final Report Year: 2011

Final Report Abstract

No abstract available

Publications

• HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. The EMBO Journal, Vol. 26. 2007, Issue 21, pp. 4423-4432.
  Herrmann S. Stieber J, StöckIG, Hofmann F, Ludwig A
  (See online at https://dx.doi.org/10.1038/sj.emboj.7601868)
• IRAG mediates NO/cGMP-dependent inhibition of platelet Aggregation and thrombus formation. Blood, Vol. 109. 2007, Issue 2, pp. 552 - 559.
  Antl M, v. Brühl M-L, Eiglsperger C, Werner M, Konrad I, Köcher T, Wilm M, Hofmann F, Massberg S, Schlossmann J
  
• Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circulation Research, Vol. 101. 2007, Issue 11, pp. 1096-1103.
  Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Feil S, Schlossmann J, Hofmann F, Feil R
  (See online at https://dx.doi.org/10.1161/CIRCRESAHA.107.154351)
• The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. The Journal of Cell Biology, vol. 179. 2007, Issue 2, pp. 331-340.
  Schmidt H, Stonkute A, Jüttner R, Schäffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG.
  (See online at https://dx.doi.org/10.1083/jcb.200707176)
• Anemia and splenomegaly in cGKI-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 18, pp. 6771 - 6776.
  Poller M, Feil S, Ghoreschi K, Koka S, Gerting A, Thunemann M, Hofmann F, Schüler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber SM, Lang F, Fell R.
  (See online at https://dx.doi.org/10.1073/pnas.0708940105)
• cGMP-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cell. Molecular Biology of the Cell, vol. 19. 2008, no. 10, pp. 4434-4441.
  Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L, Hofmann F, Feil R
  (See online at https://dx.doi.org/10.1091/mbc.E08-04-0370)
• Cysteine-rich protein 2, a novel downstream effector of cGMP / cGMPdependent protein kinase I mediated persistent inflammatory pain. The Journal of Neuroscience, Vol. 28. 2008, Issue 6, pp. 1320-1330.
  Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher, HD, Hofmann F, Tegeter 1, Ruth P, Geisslinger, G
  (See online at https://dx.doi.org/10.1523/JNEUROSCI.5037-07.2008)
• Phosphorylation of GSK-3 ß by cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth. Journal of Clinical Investigation, Vol. 118. 2008, Issue 7, pp. 2506-2515.
  Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung U, Kawaguchi H
  (See online at https://dx.doi.org/10.1172/JCI35243)
• Role of smooth muscle cGMP/cGKl signaling in murine vascular restenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 28. 2008, Issue 8, pp. 1244-1250.
  Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zemecke A, Weber C, Hofmann F, Feil R.
  (See online at https://dx.doi.org/10.1161/ATVBAHA.108.166405)
• Signaling through cGMPdependent protein kinase I in the amygdala is critical for auditorycued fear memory and long-term potentiation. Journal of Neuroscience, Vol. 28. 2008, Issue 52, pp. 14202-14212.
  Paul C. Schöberl F, Weinmeister P, Micale V, Wotjak CT, Hofmann F, Kleppisch T
  (See online at https://dx.doi.org/10.1523/JNEUROSCI.2216-08.2008)
• Tamoxifen-inducible gene deletion in the Cardiac conduction system. Journal of Molecular and Cellular Cardiology. Vol. 45. 2008, Issue 1, pp. 62–69.
  HoesI E, Stieber J, Hen-mann S, FeilS, Tybl E, Hofmann F, Feil R, Ludwig A.
  (See online at https://dx.doi.org/10.1016/j.yjmcc.2008.04.008)
• cGMP kinase and RhoA Ser188 phosphorylation integrate pro- and anti-fibrotic signals in blood vessels. Molecular and Cellular Biology, vol. 29. 2009, no. 22, pp. 6018-6032.
  Sawada N, Itoh H, Miyashita K, Tsujimoto H, Sone M, Yamahara K, Arany ZP, Hofmann F, Nakao K.
  (See online at https://dx.doi.org/10.1128/MCB.00225-09)
• cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal neovascularization. PLOS One 4: e4879.
  Aicher A, Heeschen C, Fell S, Hofmann F, Mendelsohn ME, Feil R, Dimmeler, S
  (See online at https://dx.doi.org/10.1371/journal.pone.0004879)
• cGMP-dependent Protein Kinase II and Aldosterone Secretion. FEBS Journal, Vol. 276. 2009, Issue 4, pp. 1007–1013.
  Spießberger B, Bernhard D, Herrmann S, Feil S, Werner C, Luppa PB, Hofmann F.
  (See online at https://dx.doi.org/10.1111/j.1742-4658.2008.06839.x)
• Combined reporter gene PET and iron oxide MR imaging for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart. Journal of Nuclear Medicine, Vol. 50. 2009, no. 7, pp. 1088-1094.
  Higuchi T, Anton M, Dumler K, Seidl S, Pelisek J, Saraste A, Welling A, Hofmann F, Oostendorp RAJ, Gänsbacher B, Nekolla SG, Bengel FM, BotnarRM, Schwaiger M.
  (See online at https://dx.doi.org/10.2967/jnumed.108.060665)
• Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory Neurons. Journal of Neuroscience, Vol. 29. 2009, Issue 5, pp. 1350-1360.
  Zhao Z. Wang Z. Gu Y, Fell R, Hofmann F, Ma L.
  (See online at https://dx.doi.org/10.1523/JNEUROSCI.3770-08.2009)
• Cardiac hypertrophy is not amplified by deletion of cGMPdependent protein kinase type I in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America, Vol. 107. 2010, Issue 12, pp. 5646-5651.
  Lukowski R, Rybalkin SD, Loga F. Leiss V, Beavo JA, Hofmann F.
  (See online at https://dx.doi.org/10.1073/pnas.1001360107)
• cGMP-dependent protein kinase type I promotes CREB/CRE-mediated gene expression In neurons ofthe lateral amygdala. Neuroscience Letters, Vol. 473. 2010, Issue 2, pp. 82–86.
  Paul C, Stratil C, Hofmann F, Kleppisch T.
  (See online at https://dx.doi.org/10.1016/j.neulet.2010.02.020)
• IRAG determines NO- and ANP-mediated smooth muscle relaxation. Cardiovascular Research, Vol. 86. 2010, pp. 496–505.
  Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Hocherl K, Fell R, Fell S, Lukowski R, Wegener JW, Hofmann F, Schlossmann J
  (See online at https://dx.doi.org/10.1093/cvr/cvq008)