Chronical electrical stimulation for treatment of aged voice

• Applicant: Professor Dr.-Ing. Michael Döllinger
• Subject Area: Otolaryngology, Phoniatrics and Audiology
• Term: from 2018 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 409543779

• Final Report Year: 2022

Final Report Abstract

The following scientific progress and impact concerning the application of FES treatment to counteract the effects of muscle atrophy can be reported: (1) successfull bilateral implantation of stimulation electrodes in aged sheep, (2) increased TAM muscle fiber diameter and slightly increased TAM muscle volume, (3) successful functional testing of twelve ex vivo sheep larynges (six sham and six stimulated), and (4) improved voice production of stimulated larynges compared to sham larynges but unclear effect of age as shown by statistical analysis including data of unstimulated old and young sheep larynges from preliminary studies.

Publications

• "Comparison of acoustic signal quality with respect to glottal closure between old and young ex vivo sheep larynges”. In: The 14th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research (AQL). Bogota, Columbia, 2021
  B. Jakubaß, M. Gugatschka, C. Gerstenberger, M. Semmler, and M. Döllinger
  
• A Deep Learning Enhanced Novel Software Tool for Laryngeal Dynamics Analysis. Journal of Speech, Language, and Hearing Research, 64(6), 1889-1903.
  Kist, Andreas M.; Gómez, Pablo; Dubrovskiy, Denis; Schlegel, Patrick; Kunduk, Melda; Echternach, Matthias; Patel, Rita; Semmler, Marion; Bohr, Christopher; Dürr, Stephan; Schützenberger, Anne & Döllinger, Michael
  
• "Influence of functional electric stimulation on phonation in an ex-vivo ovine model”. PhD thesis. Friedrich- Alexander-Universität Erlangen-Nürnberg, 2022
  B. Jakubaß
  
• "Untersuchung der Auswirkungen von FES als potentielle Therapie der Altersstimme am ex-vivo Schafmodell”. In: 38. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP). Leipzig, Germany, 2022
  B. Jakubaß, G. Peters, M. Gugatschka, C. Gerstenberger, S. Kniesburges, M. Semmler, and M. Döllinger
  
• Effekte von bilateraler Stimulation der Rekurrensparese bei Presbyphonie”. In: Österreichischer HNO- Kongress. Graz, Austria, 2022
  M. Gugatschka
  
• Re-Training of Convolutional Neural Networks for Glottis Segmentation in Endoscopic High-Speed Videos. Applied Sciences, 12(19), 9791.
  Döllinger, Michael; Schraut, Tobias; Henrich, Lea A.; Chhetri, Dinesh; Echternach, Matthias; Johnson, Aaron M.; Kunduk, Melda; Maryn, Youri; Patel, Rita R.; Samlan, Robin; Semmler, Marion & Schützenberger, Anne
  
• Effect of functional electric stimulation on phonation in an ex vivo aged ovine model. The Journal of the Acoustical Society of America, 153(5), 2803.
  Jakubaß, Bernhard; Peters, Gregor; Kniesburges, Stefan; Semmler, Marion; Kirsch, Andrijana; Gerstenberger, Claus; Gugatschka, Markus & Döllinger, Michael