FOR 3004:  Synaptic pathology in autoimmune encephalitis – SYNABS

• Subject Area: Medicine
• Term: since 2019
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 415914819

The coordination project comprises the central administration and coordination of the RU. It includes the costs for internal meetings, workshops, and lab exchanges for young scientists. It will also develop the public appearance of the RU including hosting of the web page, public relation, and organization and support of RU members for presentation in international congresses and symposia. The coordination project will also organize the Mercator fellowship of Professor Dalmau and Professor Fukata including research stays and visits. To support young academics the coordination project will coordinate special courses, e.g. during the annual meetings of young scientists and promote mentoring measures. The career of female scientists will be further supported by measures of the association `Wissenschaftler:innen und Karriere Jena` (WKJ) to increase the amount of female researchers in scientific leadership positions.

• DFG Programme: Research Units
• International Connection: Austria

Projects

• Antibody neutralization for treatment of autoimmune encephalitis (Applicants Hallermann, Stefan ;  Hust, Michael )
• Coordination Funds (Applicant Geis, Christian )
• Developmental and synaptic defects caused by transplacental transmission of NMDA receptor antibodies (Applicants Kaindl, Angela ;  Kirmse, Knut ;  Prüß, Harald )
• Developmental defects caused by transplacental transmission of autoantibodies against NMDA receptors and further neuronal antigens (Applicants Kaindl, Angela ;  Kirmse, Knut ;  Kreye, Jakob )
• Direct and acute effects of human monoclonal anti-GluN1 autoantibodies on NMDA receptor channel function (Applicants Geis, Christian ;  Heckmann, Manfred )
• Glycine receptor autoantibodies and spinal disinhibition (Applicants Sommer, Claudia ;  Villmann, Carmen )
• Glycine receptor autoantibodies and spinal disinhibition (Applicants Qualmann, Britta ;  Villmann, Carmen )
• LGI1 antibody induced pathophysiology at axon initial segments and presynaptic nerve terminals (Applicants Hallermann, Stefan ;  Sauer, Markus )
• Molecular mechanisms and in-vivo functional effects of antibodies in GABAB receptor autoimmune encephalitis (Applicants Geis, Christian ;  Kornau, Hans-Christian ;  Schmidt-Hieber, Christoph )
• Origin and Diversity of Pathogenic Human Monoclonal Antibodies and T cells in Tumor-associated Autoimmune Neurological Disorders (Applicants Prüß, Harald ;  Wahl, Ilka Maria )
• Origin and diversity of pathogenic human monoclonal antibodies to the NMDA receptor (Applicants Prüß, Harald ;  Wardemann, Hedda )
• P4 Impact of IgLON5 autoantibodies on cerebellar circuits and neuronal pathology in human patients and mouse models (Applicant Liebscher, Sabine )

• Spokesperson: Professor Dr. Christian Geis