Unraveling the role of brown adipose tissue in myocardial ischemia/reperfusion injury (B10)

• Subject Area: Cardiology, Angiology ; Endocrinology, Diabetology, Metabolism
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352

B10 aims to explore the so far unknown role of brown adipose tissue (BAT) in AMI using cutting-edge MR techniques. For this, BAT activation will be investigated pre- and post-I/R by a novel MRI T2 mapping approach as well as classical histological and molecular biology methods. In parallel, sub¬strate metabolism will be longitudinally studied by non-invasive MR techniques for lipid profiling and glucose uptake in BAT and heart. BAT ablation will be utilized to elucidate its role for functional out¬come post I/R. Analyses will be expanded to diabetic conditions in a murine model and experimental data will be completed by first translational MR analyses of BAT activation in patients post AMI.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1116: Master switches in cardiac ischemia
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Heads: Professor Dr. Ulrich Flögel; Professorin Dr. Maria Grandoch