Sources and consequences of intrinsic genomic instability across human cell types (13)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 393547839

This project aims to uncover how the influences of transcription, DNA topology and replication converge to determine which regions of the genome preferentially break. We will investigate whether intrinsic DNA fragility varies between cell types and how this relates to genomic rearrangements found in cancer. To address this, we include a fullyfledged bioinformatics pillar to combine elaborate genomics approaches with multi-modal data integration, quantitative comparisons and machine learning. Our project thereby provides both experimental and computational tools to study genomic instability and strongly contributes to the enhanced emphasis of the consortium on systems approaches.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1361: Regulation of DNA Repair and Genome Stability
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Vassilis Roukos; Dr. Katharina Zarnack, since 1/2023