Controllable dissolution of sol-gel derived borate glasses for accelerating wound healing
Final Report Abstract
Binary B2O3-CaO and ternary B2O3-CaO-CuO borate BGs were successfully synthesized using sol-gel-based methods. Thanks to the convenience of sol-gel chemistry, borate BGs with simple composition systems were produced for the first time. The morphology, structure and ion release behavior of borate BGs were investigated in detail. The results confirmed that the dissolution behavior (ion release) of sol-gel derived binary and ternary borate-based BGs can be controlled by tuning their chemical compositions. We also evaluated the in vitro cytotoxicity, hemostatic, antibacterial and angiogenic activities of the newly developed borate BGs. The results indicated that the biological properties of borate BGs were composition-dependent and dose-dependent. Optimizing the composition and concentration used allows us to obtain borate BGs that can be used in medical devices, e.g., wound dressings, that can accelerate wound healing by promoting hemostatic, antibacterial and angiogenic performances. Overall, the results of this project provide knowledge for the sol-gel synthesis of a new family of borate BGs, which has not been widely investigated yet. The obtained borate BGs can be used to develop novel biomedical devices for chronic wound healing, given their tunable composition, ion release behavior and favorable hemostatic, antibacterial and angiogenic activities. However before planning in vivo studies, further cell biology studies to assess the mid and long term effect of ion release from the developed nanoparticles is required.
Publications
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Porous bioactive glass micro- and nanospheres with controlled morphology: developments, properties and emerging biomedical applications. Materials Horizons, 8(2), 300-335.
Zheng, Kai; Sui, Baiyan; Ilyas, Kanwal & Boccaccini, Aldo R.
