Epigenetic and transcriptional alterations in pancreatic cancer - influence on molecular subtypes, chemosensitivity, and metastatic potential

• Applicant: Dr. Andreas Carl-Stephan Leonhardt
• Subject Area: General and Visceral Surgery
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 423165260

• Final Report Year: 2022

No abstract available

Publications

• (2019). Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer. Cancer discovery, 9(9), 1268-1287
  Humpton, Timothy J.; Alagesan, Brinda; DeNicola, Gina M.; Lu, Dan; Yordanov, Georgi N.; Leonhardt, Carl S.; Yao, Melissa A.; Alagesan, Priya; Zaatari, Maya N.; Park, Youngkyu; Skepper, Jeremy N.; Macleod, Kay F.; Perez-Mancera, Pedro A.; Murphy, Michael P.; Evan, Gerard I.; Vousden, Karen H. & Tuveson, David A.
  
• Adjuvant and Neoadjuvant Chemotherapy in Pancreatic Ductal Adenocarcinoma. Journal of Pancreatology: 2020 Mar 3;1/1-11
  Leonhardt, Carl S.; Traub, Benno; Hackert, Thilo; Klaiber, Ulla; Strobel, Oliver; Büchler, Markus W. & Neoptolemos, John P.
  
• Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.
  Le Blanc, Solange; Ishaque, Naveed; Jabs, Julia; Bauer, Tobias; Schuth, Sebastian; Hu, Qing; Debnath, Olivia; Ten, Foo Wei; Leonhardt, Carl-Stephan; König, Anna-Katharina; Bieg, Matthias; Eckert, Christoph; Gaida, Matthias M.; Volkmar, Michael; Hübschmann, Daniel; Schenk, Miriam; Offringa, Rienk; Giese, Nathalia A.; Schlesner, Matthias; ... & Strobel, Oliver
  
• Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy. Nat Commun. 2021 Oct 5;12(1):582
  Krieger, Teresa G.; Le Blanc, Solange; Jabs, Julia; Ten, Foo Wei; Ishaque, Naveed; Jechow, Katharina; Debnath, Olivia; Leonhardt, Carl-Stephan; Giri, Anamika; Eils, Roland; Strobel, Oliver & Conrad, Christian