Project Details
Projekt
Elucidating tumor-associated microglia interactions in astrocytomas CNS WHO-Grad 4 (A04)
Subject Area
Hematology, Oncology
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405
In this project, we aim to understand how tumor subpopulations influence the transcriptional states of tumor associated microglia (TAM) in malignant astrocytomas harboring isocitrate dehydrogenase (IDH) mutations. Dynamic and complex interactions occur between gliomas and TAM in the tumor microenvironment and these interactions are further compounded by tumor heterogeneity. However, specific molecular interactions between tumor subpopulations and TAM states remain unresolved. An understanding of how specific alterations in tumors impact the TAM microenvironment will be important for development of novel therapeutic options for the treatment of glioma patients.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Sevin Turcan, Ph.D.
