DNA mis-match repair regulates immune checkpoint blockade therapy in glioblastoma (B02)

• Subject Area: Hematology, Oncology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 404521405

This project focuses on the genetic dissection of the role of DNA mismatch repair deficiency in immune checkpoint inhibitor therapy against glioblastoma in vivo. We aim to identify druggable regulators which may sensitize to immune therapy in glioblastoma.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1389: Understanding and Targeting Resistance in Glioblastoma (UNITE Glioblastoma)
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Dr. Hai-Kun Liu, Ph.D.