Organtoxizität durch Nukleosidanaloga in der HIV-Therapie im Mausmodell - Therapeutische Beeinflussbarkeit durch Uridin

Applicant Professor Dr. Ulrich A. Walker

Subject Area Rheumatology

Term from 2007 to 2010

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 42492194

Final Report Year 2012

Final Report Abstract

No abstract available

Uridine supplementation antagonizes zidovudine-induced mitochondrial myopathy and hyperlactatemia. Arthritis Rheum. (2008) 58:318-326
D. Lebrecht, C. Deveaud, B. Beauvoit, J. Bonnet, J. Kirschner and UA. Walker
Gene transcription profiles and immunohistochemistry in adipose tissue of HIV-1 infected patients with NRTI-associated lipoatrophy. J Infect Dis. (2009) 200:252-262
UA. Walker, M. Sievers, K. Sevastianova, B. Setzer, D. Wågsäter, P. Eriksson, H. Yki-Järvinen and J. Sutinen
Mitochondrial tubulopathy in tenofovir-DF treated rats. JAIDS (2009) 51:258-263
D. Lebrecht, AC. Venhoff, J. Kirschner, T. Wiech, N. Venhoff and UA. Walker
MtDNA depletion in rat liver induced by fosalvudine tidoxil, a novel NRTI pro-drug. Antimicrobial Agents Chemother. (2009) 53:2748-51
AC. Venhoff, D. Lebrecht, FU. Reuss, B. Heckl-Östreicher, R. Wehr, UA. Walker and N. Venhoff
Uridine supplementation with Mitocnol attenuates mitochondrial cardiomyopathy induced by zidovudine and zalcitabine. JAIDS. (2010)
K. Balcarek, D. Lebrecht, C. Deveaud, B. Beauvoid, J. Bonnet, JB. Kirschner, N. Venhoff and UA. Walker
(See online at https://doi.org/10.1097/QAI.0b013e3181f25946)
Uridine supplementation with Mitocnol attenuates the peripheral neuropathy and encephalopathy induced by antiretroviral nucleoside analogues. AIDS (2010) 24:345-52
N. Venhoff, C. Deveaud, B. Beauvoit, J. Bonnet, AC. Venhoff, K. Müller, J. Kirschner, D. Lebrecht and UA. Walker