Die Funktion von Interleukin-3 in chronisch-entzündlichen Darmerkrankungen

• Antragsteller: Alan Bénard, Ph.D.
• Fachliche Zuordnung: Allgemein- und Viszeralchirurgie ; Immunologie
• Förderung: Förderung von 2019 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 424983853

• Erstellungsjahr: 2021

Zusammenfassung der Projektergebnisse

Our data identified interleukin-3 as an important protective mediator during colitis. Mechanistically, we observed that the production of interleukin-3 by mesenchemal stem cells promoted the early recruitment of splenic emergency neutrophils into the colon via CCL5+ T cells. However, we did not yet identify the CD123+ cells involved in this process. We also showed that interleukin-3 drove extramedullary haematopoiesis in spleen thereby sustaining neutrophil mobilization. Our data suggest that the protective effect of IL-3 during colitis is not restricted to splenic neutrophil recruitment but involves other mechanisms. Further investigations are therefore necessary to fully understand the role of IL-3 during colitis.

Projektbezogene Publikationen (Auswahl)

• (2019). Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer-A Single Centre Experience. Cancers (Basel). 2019 Apr 30;11
  Kalb, Maximilian; Langheinrich, Melanie C.; Merkel, Susanne; Krautz, Christian; Brunner, Maximilian; Bénard, Alan; Weber, Klaus; Pilarsky, Christian; Grützmann, Robert & Weber, Georg F.
  
• (2020). The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLoS Pathog. 2020 Apr 23;16
  Fernandes, Vitor E.; Ercoli, Giuseppe; Bénard, Alan; Brandl, Carolin; Fahnenstiel, Hannah; Müller-Winkler, Jennifer; Weber, Georg F.; Denny, Paul; Nitschke, Lars & Andrew, Peter W.
  
• (2020). Upregulation of CD20 Positive B-Cells and B-Cell Aggregates in the Tumor Infiltration Zone is Associated with Better Survival of Patients with Pancreatic Ductal Adenocarcinoma. Int J Mol Sci. 2020 Mar 5;21
  Brunner, Maximilian; Maier, Katharina; Rümmele, Petra; Jacobsen, Anne; Merkel, Susanne; Benard, Alan; Krautz, Christian; Kersting, Stephan; Grützmann, Robert & Weber, Georg F.
  
• (2021) Colorectal cancer in Crohn's colitis is associated with advanced tumor invasion and a poorer survival compared with ulcerative colitis: a retrospective dual-center study. Int J Colorectal Dis. 2021 Jan;36(1):141-150
  Vetter, Leonie E.; Merkel, Susanne; Bénard, Alan; Krautz, Christian; Brunner, Maximilian; Mittelstädt, Anke; Schlegel, Nicolas; Wiegering, Armin; Germer, Christoph-Thomas; Weber, Klaus; Grützmann, Robert & Weber, Georg F.
  
• (2021) Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. Nat Commun. 2021 Feb 18;12(1):1112
  Bénard, Alan; Jacobsen, Anne; Brunner, Maximilian; Krautz, Christian; Klösch, Bettina; Swierzy, Izabela; Naschberger, Elisabeth; Podolska, Malgorzata J.; Kouhestani, Dina; David, Paul; Birkholz, Torsten; Castellanos, Ixchel; Trufa, Denis; Sirbu, Horia; Vetter, Marcel; Kremer, Andreas E.; Hildner, Kai; Hecker, Andreas; Edinger, Fabian; ... & Weber, Georg F.