Project Details
Projekt
Metabolic regulation of macrophage activation in haemophagocytic lymphohistiocytosis (HLH) (C04*)
Subject Area
Immunology
Rheumatology
Rheumatology
Term
from 2019 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931
Excessive, unregulated macrophage activation is linked to disease development in haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Macrophage activation is regulated metabolically, and inhibition of metabolic processes linked to activation offers an opportunity to control HLH/MAS. In this context, the project has two aims: 1) To characterize the metabolism, as related to function, of macrophages from a mouse model of HLH and from HLH/MAS patients, and 2) To block macrophage activation in HLH/MAS using small molecule inhibitors of key metabolic enzymes.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1160:
Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
Applicant Institution
Albert-Ludwigs-Universität Freiburg
Project Head
Professor Dr. Edward Pearce, Ph.D.
