Functional proteomics dissection of chemotactic protein diversity (A13*)

• Subject Area: Biochemistry
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

Chemotactic protein activity is regulated at multiple levels, including post-translational modifications. In this project, we will test the hypothesis that divergent paracrine activities arise from differentially modified chemotactic protein variants (proteoforms) by combining proteomics discovery technologies, systems biology and functional validation approaches. Thereby, we will establish a system-level view of chemokine proteoform diversity and will generate new insights about how paracrine signals and their modifications affect cell signaling and chemotaxis during tissue homeostasis and inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Felix Meissner