Role of cytosolic MRP8/14 in leukocyte recruitment in vivo (B11*)

• Subject Area: Immunology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

The project intends to identify the function of intracellular MRP8/14 (S100A8/A9, calprotectin) in neutrophil recruitment. We aim to uncover the role of cytosolic MRP8/14 in postarrest modification steps, like spreading, adhesion strengthening and Ca2+ dependent cytoskeletal rearrangement. Furthermore, we will study the influence of MRP8/14 in neutrophil transendothelial migration and interstitial migration. In order to achieve these aims we will combine in vivo studies using different mouse inflammation models with in vitro assays.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Dr. Monika Prünster