Assembly of PTH/polymer hybrid molecules (A12*)

• Subject Area: Biophysics ; Experimental and Theoretical Physics of Polymers ; Preparatory and Physical Chemistry of Polymers
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 189853844

The molecular ordering of reversibly aggregating parathyroid hormone conjugated to switchable synthetic polymers will be investigated. Amyloid assembly will be modulated by the switchable polymer upon external stimuli including temperature, solvent and light. Both, the protein and polymer entity will influence the properties of the hybrid partner allowing conformational studies and mechanistic insights into the assembly mechanism. These hybrid molecules harbor a wealth of physico-chemical properties, which we aim to understand based on fundamental principles.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 102: Polymers under Multiple Constraints: Restricted and Controlled Molecular Order and Mobility
• Applicant Institution: Martin-Luther-Universität Halle-Wittenberg
• Project Heads: Professor Dr. Jochen Balbach; Professor Dr. Wolfgang Binder