High-throughput incubation and imaging system for crystal growth

• Subject Area: Basic Research in Biology and Medicine
• Term: Funded in 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 429649016

A high-throughput system is required for the documentation, analysis and optimization of crystallization experiments and the sensitive identification of protein crystals. The system will allow the automated tracking of crystallization experiments over a period of several weeks at a constant temperature. The nucleation and growth of protein crystals will be reliably documented, even under difficult optical conditions, in the presence of aggregated material and salt crystals. The system will support a variety of plate formats. A modular design of the system based on exchangeable standard components is preferred.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Hochdurchsatz Inkubations- und Bildgebungssystem zur Kristallzüchtung
• Instrumentation Group: 1170 Kristallzüchtungsapparaturen, Kristallisationsanlagen
• Applicant Institution: Medizinische Hochschule Hannover
• Leader: Professor Dr. Dietmar J. Manstein