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Checkpoints determining recovery from acute autoimmune CNS grey matter lesions (A03)

Subject Area Molecular and Cellular Neurology and Neuropathology
Term since 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537
 
This project focuses on recovery mechanisms of the CNS tissue in the course of acute T-cell mediated autoimmune inflammation. We hypothesize that T-cell induced changes of the grey matter are crucial for the failing recovery of the CNS after repeated autoimmune bouts and that lung microbiota are external regulators of de- and regenerative processes within the CNS tissue. We aim to identify brain-resident and peripheral targets to prevent permanent CNS damage and/or to foster its recovery which might in perspective be exploited to develop novel therapeutic strategies.
DFG Programme CRC/Transregios
Applicant Institution Georg-August-Universität Göttingen
 
 

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