Glial checkpoints for neuronal circuitry recovery (C05)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537

Neuronal loss in acute or chronic brain disease could be treated by neuronal replacement strategies, such as transplantation of young neurons, if they integrate properly into the existing networks. Here we explore the cell-based and molecular mechanisms causing hyperinnervation and overshoot loss of input connectivity as well as the newly discovered hurdle in output connectivity, the lack of myelination. Candidate as well as unbiased approaches are pursued to identify the critical checkpoints and overcome them.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 274: Checkpoints of Central Nervous System Recovery
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professorin Dr. Magdalena Götz; Professor Dr. Martin Kerschensteiner, until 12/2023