FOR 5146:  Defining the osteohepatic axis in the context of iron homeostasis - FerrOs

• Subject Area: Medicine
• Term: since 2020
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 436298031

No abstract available

• DFG Programme: Research Units
• International Connection: Switzerland

Projects

• 4-“T”-interplay (Type I BMP Receptors/TFR1/TFR2/TMPRSS6) in iron sensing and bone homeostasis. (Applicant Steinbicker, Andrea Ulrike )
• Coordination Funds (Applicant Rauner, Martina )
• Deconstructing cell metabolic pathways causing iron toxicity-induced inhibition of osteoblast function, induction of FGF-23, and osteomalacia (Applicant Rauner, Martina )
• Defining the role of the iron-sensor Tfr2 in ossification processes (Applicant Baschant, Ulrike )
• Exploring TFR2 as a central hub of mitochondrial metabolism within the liver-bone-inflammation axis (Applicant Ledesma Colunga, Ph.D., Maria G. )
• Identification of iron-related signals controlling BMP expression in liver non-parenchymal cells (Applicant Muckenthaler, Martina )
• Impact of iron and anemia on bone metabolism and fractures (Applicants Burden, Ph.D., Andrea ;  Hofbauer, Lorenz C. ;  Steinbicker, Andrea Ulrike )
• Molecular mechanisms of ferroportin-mediated protection against bone diseases (Applicants Altamura, Sandro ;  Hofbauer, Lorenz C. )
• P7 Employing a systems biology approach to unravel organism-wide and hepatocyte-specific iron-dependent mechanisms regulating BMP signal transduction (Applicant Klingmüller, Ursula )
• Role of iron in bone metabolism of Hfe-hemochromatosis (Applicant Vujic Spasic, Ph.D., Maja )

• Spokesperson: Professorin Dr. Martina Rauner