Calcium Channels, NO and Synaptic Plasticity

• Applicant: Professor Dr. Franz Hofmann
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2007 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 43864266

• Final Report Year: 2011

Final Report Abstract

No abstract available

Publications

• (2007) Analysis of calcium channels by conditional mutagenesis. In Conditional Mutagenesis: An Approach to Disease Models. Eds. Feil R, Metzger, D. Handbook of Experimental Pharmacology 178, 465-486
  Moosmang S, Kleppisch T, Wegener J, Welling A, Hofmann F
  
• (2007) Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons. J Neurosci. 27(32): 8719-8732
  Ying S-W, Jia F, Abbas SY, Hofmann F, Ludwig A, Goldstein PA
  
• (2007) Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circ Res 101: 1096-1103
  Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Feil S, Schlossmann J, Hofmann F, Feil R
  
• (2007) The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol 179, 331-340
  Schmidt H, Stonkute A, Jüttner R, Schäffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG
  
• (2008) Cav1.2 Calcium Channels modulate the spiking pattern of hippocampal pyramidal cells. Life Sciences 82: 41-49
  Lacinova L, Moosmang S, Langwieser N, Hofmann F, Kleppisch T
  (See online at https://doi.org/10.1016/j.lfs.2007.10.009)
• (2008) Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I mediated persistent inflammatory pain. J Neurosci 28:1320-1330
  Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher H-D, Hofmann F, Tegeter I, Ruth P, Geisslinger G
  
• (2008) Signaling through cGMP-dependent protein kinase I in the amygdala is critical for auditory-cued fear memory and long-term potentiation. J Neurosci 28:14202-14212
  Paul C, Schöberl F, Weinmeister P, Micale V, Wotjak CT, Hofmann F, Kleppisch T
  
• (2008) Voltage-dependent Calcium Channels. In: Encyclopedic Reference of Molecular Pharmacology, 2nd edition, eds: Offermanns S, Rosenthal W; Springer-Verlag pp. 1301-1305
  Hofmann F
  
• (2009) Regulate Axon Branching by the Cyclic GMP Pathway via Inhibition of Glycogen Synthase Kinase 3 in Dorsal Root Ganglion Sensory Neurons. J Neurosci 29: 1350-1360
  Zhao Z, Wang Z, Gu Y, Feil R, Hofmann F, Ma L
  
• (2010) cGMP-dependent protein kinase type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala. Neurosci Lett. 473: 82-86
  Paul C, Stratil C, Hofmann F, Kleppisch T
  
• (2010) Electrical activity suppresses axon growth through Cav1.2 channels in adult primary sensory neurons. Curr. Biol 20: 1154-1164
  Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez MM, Klug A, Traut MH, Ylera B, Tahirovic S, Hofmann F, Stein V, Moosmang S, Hentall ID, Bradke F
  
• (2010) Homeostatic switch in Hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels. J Neurosci 30: 8367-8375
  Langwieser N, Christel CJ, Kleppisch T, Hofmann F, Wotjak C, Moosmang S
  
• (2010) L-Type Calcium Channel Cav1.2 in Transgenic Mice Overexpressing Human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) Mutations. J Alzheimers Dis. 20(4):1167-80
  Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, Günther Knaus H, Marksteiner J
  
• (2011) HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life 68(1):125-137. Epub 2010 Jul 10
  Matt L, Michalakis S, Hofmann F, Hammelmann V, Ludwig A, Biel M, Kleppisch, T
  
• (2011) The cGMP-dependent protein kinase II is an inhibitory modulator of the hyperpolarization-activated HCN2 channel. PLOS One 6(2): e17078
  Hammelmann V, Zong X, Hofmann F, Michalakis S, Biel M