Enzyme-like FLP Catalysis within Coordination Cages
Final Report Abstract
The flow of stereochemical information, such as the chiral recognition of steroids and saccharides by receptors, and the stereoselective transformations by enzymes, is integral to living systems. Artificial molecular systems such as metal-organic cages that can mimic the behaviors of biomolecules are important in understanding the molecular basis of binding in relevant biological processes, which may led to the development of bioinspired applications. We sysmetically investigated the diastereoselectivity and stereochemical information transfer during the self-assembly of chiral metal-organic cages, including one Zn8L6 cubic and two Fe4L4 tetrahedral cages. These cages exhibited remarkable enzyme-like conformational plasticity and chirality switching in response to external stimuli, such as solvent, temperature, and guest binding. The strategy outlined in our studies may be applicable to the design of stimuli-responsive chiral switchable materials. Furthermore, the applications of such dynamic systems were demonstrated in chiral separation and selective extraction, which may pave the way for new cage-based purification methods.
Publications
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Solvent Drives Switching between Λ and Δ Metal Center Stereochemistry of M8L6 Cubic Cages. Journal of the American Chemical Society, 144(14), 6136-6142.
Xue, Weichao; Ronson, Tanya K.; Lu, Zifei & Nitschke, Jonathan R.
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A Diverse Array of Large Capsules Transform in Response to Stimuli. Journal of the American Chemical Society, 145(20), 11356-11363.
Wu, Kai; Ronson, Tanya K.; Goh, Leonard; Xue, Weichao; Heard, Andrew W.; Su, Pingru; Li, Xiaopeng; Vinković, Mladen & Nitschke, Jonathan R.
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Allosterically Regulated Guest Binding Determines Framework Symmetry for an FeII4L4 Cage. Angewandte Chemie International Edition, 62(18).
Xue, Weichao; Wu, Kai; Ouyang, Nianfeng; Brotin, Thierry & Nitschke, Jonathan R.
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Subtle Stereochemical Effects Influence Binding and Purification Abilities of an FeII4L4 Cage. Journal of the American Chemical Society, 145(9), 5570-5577.
Xue, Weichao; Pesce, Luca; Bellamkonda, Adinarayana; Ronson, Tanya K.; Wu, Kai; Zhang, Dawei; Vanthuyne, Nicolas; Brotin, Thierry; Martinez, Alexandre; Pavan, Giovanni M. & Nitschke, Jonathan R.
