SFB 1479:  Oncogene-driven immune escape (OncoEscape)

• Subject Area: Medicine ; Biology
• Term: since 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 441891347

No abstract available

• DFG Programme: Collaborative Research Centres
• International Connection: Switzerland

Current projects

• P01 - Counteracting NRAS- and c-KIT-driven immune escape in AML by kinase inhibition and T-cell reprogramming (Project Heads Blaeschke, Franziska ;  Zeiser, Robert )
• P02 - Targetable modifiers of T cell exclusion in KrasG12D-driven colorectal cancer liver metastases (Project Head Greten, Florian R. )
• P03 - Effects of cKit-D816V and FLT3-ITD on tissue factor-mediated immune escape in acute myeloid leukaemia (Project Heads Briquez, Ph.D., Priscilla ;  Köhler, Natalie )
• P05 - Flt3-ITD-induced remodelling of non-leukaemic myeloid cells and its role in leukaemic immune escape (Project Heads Apostolova, Petya ;  Cabezas-Wallscheid, Nina ;  Kierdorf, Katrin )
• P07 - Dissecting myeloid subset-specific effects of the IDH1 mutation in high-grade glioma (Project Head Prinz, Marco )
• P08 - Therapeutic exploitation of immunosuppressive aberrant tubular repair in VHL mutant clear cell renal cell carcinoma (Project Head Frew, Ian )
• P10 - Targeting the parenchymal and immune proto-oncogenic ER-stress/ ATF6 - axis in liver cancer (Project Heads Heikenwälder, Mathias ;  Hofmann, Maike )
• P12 - Oncogenic BRAF-V600E drives immune escape via prostaglandin E2/oncostatin M production in melanoma (Project Heads Duyster, Justus ;  Kolter, Julia )
• P14 - Overcoming immune evasion of BRAF mutant colorectal cancer (Project Head Brummer, Tilman )
• P15 - Project title: Engineering γδT cells to target oncogenic hubs (Project Head Minguet, Ph.D., Susana )
• P17 - Dual RAS/SHP2 inhibition for sensitization of pancreatic cancer to immunotherapy (Project Heads Bengsch, Ph.D., Bertram ;  Ruess, Dietrich )
• P18 - Impact of oncogenic IDH mutation on the extracellular matrix to mediate immune evasion in glioma (Project Heads Höfflin, Rouven ;  Sevenich, Lisa )
• P19 - Focal adhesion kinase (FAK) dependent immune escape in hepatocellular carcinoma (Project Heads Hofmann, Maike ;  Röhlen, Natascha )
• P20 - Targeting KMT9 to reprogramme immune cells in the tumour immune microenvironment in prostate cancer (Project Head Metzger, Ph.D., Eric )
• P21 - Targeting the COX-PGE2-EP2/EP4 axis to overcome immune escape in KRAS-G12D-mutant PDAC (Project Head Böttcher, Jan Philipp )
• P22 - Overcoming immune escape of KMT2A-rearranged acute leukaemia during immune recognition (Project Heads Feuchtinger, Tobias ;  Maas-Bauer, Kristina )
• P23 - Spatiotemporal Analysis of Immune Evasion Mechanisms in AKT1-mutant Brain Metastasis (Project Heads Ingelfinger, Florian ;  Sevenich, Lisa )
• P24 - Restoring immune surveillance in post-transplant AML by targeting the c-MYC/FLT3-ITD/TAK1 axis (Project Heads Vinnakota, Janaki Manoja ;  Wertheimer, Tobias )
• P25 - Oncogenic NFE2 induces immunosuppressive TGF-β in the bone marrow microenvironment of myeloproliferative diseases (Project Heads Pahl, Heike L. ;  Rizzi, Marta )
• S01 - S1: Data analysis, integration, and modelling (Project Heads Börries, Melanie ;  Köttgen, Anna ;  Schell, Christoph B. ;  Schilling, Oliver )
• S02 - S2: Preclinical Imaging and NMR Spectroscopy (Project Heads Reichardt, Wilfried ;  Talvard-Balland, Nana ;  Zeiser, Robert )
• Z01 - Serviceprojekt (Project Head Zeiser, Robert )
• Z02 - INF: Information Infrastructure for Research Data Management (Project Head Binder, Harald )
• Z03 - Integrated Research Training Group (IRTG) for oncogene-driven immune escape (Project Head Börries, Melanie )

Completed projects

• P04 - The role of the NPM-ALK / PD-1 axis for immune response to T cell lymphoma (Project Head Illert, Lena )
• P06 - Oncogene-driven inflammasome activity in myeloid neoplasms and its impact on leukaemia development and anti-cancer immunity (Project Head Groß, Olaf )
• P13 - The role of HRAS downstream signalling for the production of immunosuppressive metabolites in the microenvironment of HRAS-driven SCC (Project Heads Kiritsi, Dimitra ;  Nyström, Alexander )
• P16 - Understanding the crosstalk between juvenile myelomonocytic leukaemia (JMML) and immune cells (Project Heads Bengsch, Ph.D., Bertram ;  Erlacher, Miriam )

• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Participating Institution: Deutsches Krebsforschungszentrum (DKFZ); Deutsches Konsortium für Translationale Krebsforschung (DKTK); Deutsches Krebsforschungszentrum (DKFZ); Georg-Speyer-Haus ; Institut für Biomedizinische Forschung; Eberhard Karls Universität Tübingen; Medizinische Fakultät und Universitätsklinikum Tübingen; M3 Research Centre: Malignom, Metabolome and Microbiome
• Spokesperson: Professor Dr. Robert Zeiser