Role of glial-neuronal metabolic communication in autoimmune neuroinflammation
Final Report Abstract
In recent years, many pathophysiological aspects of Neuromyelitis optica spectrum disorder (NMOSD) have been better understood, which has significantly contributed to the approval of clinically highly effective therapies. However, this rare disease remains a clinical challenge in relatively young individuals due to the severity of a single attack with poor resolution tendency and lack of prognostic biomarkers. In my work, I have contributed to a deeper understanding of degenerative and regenerative processes of NMOSD lesions by establishing innovative NMOSD animal models, thereby laying the groundwork for future biomarker research and neuroprotective strategies. In doing so, I have encountered hitherto unknown mechanisms of axonal damage and regeneration of adult astrocytes, which could play a role not only in the context of NMOSD but also in neuroinflammatory conditions in general. The question of degeneration and regeneration in the context of neuroinflammation, particularly NMOSD, is certainly still not completely answered, and therefore, the exploration of further aspects such as metabolic aspects of neuronal pathology in NMOSD will remain to be important.
Publications
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P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica. Neurotherapeutics, 19(5), 1603-1616.
Kalluri, Sudhakar Reddy; Srivastava, Rajneesh; Kenet, Selin; Tanti, Goutam K.; Dornmair, Klaus; Bennett, Jeffrey L.; Misgeld, Thomas; Hemmer, Bernhard; Wyss, Matthias T. & Herwerth, Marina
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Axon degeneration: new actor in an old play. Neural Regeneration Research, 18(3), 547.
Herwerth, Marina & Wyss, MatthiasT
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The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases. Neural Regeneration Research, 19(6), 1206-1211.
Wyss, Matthias T.; Heuer, Christine & Herwerth, Marina
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Two-photon imaging of astrocytopathy-driven neuroinflammation reveals high proliferating and migratory capabilities of perilesional astrocytes. Poster presented at the Gordon Conference, 03/2023
Marina Herwerth, Matthias T. Wyss, Nicola B. Schmid, Jacqueline Condrau, Jeffrey L. Bennett, Aiman S. Saab, Sebastian Jessberger & Bruno Weber
