Geometry driven assembly of proteins (A13*)

• Subject Area: Mathematics
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 195170736

The assembly of proteins, and more generally their structure and shape in relation to function, have been a fascinating journey at the cutting edge of science over the past century. While all-atom ab-initio molecular dynamics simulations of protein behaviour are numerous, larger-scale processes of interest such as, say, virus shell self-assembly lie beyond reach of this approach; a coarse-grained description of the proteins is needed. In this project we will explore the question whether such assembly processes can be explained via a recently introduced geometry-based model for the solvation free energy of the protein.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 109: Discretisation in Geometry and Dynamics
• Applicant Institution: Technische Universität Berlin
• Project Heads: Professorin Dr. Myfanwy E. Evans; Professor Dr. Gero Friesecke