The protective function of Interleukin-3 in secondary viral pneumonia during the immunosuppressive phase of sepsis

• Applicant: Professor Dr. Georg Weber
• Subject Area: General and Visceral Surgery ; Immunology
• Term: from 2020 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 444596733

• Final Report Year: 2024

Final Report Abstract

We explored the function of IL-3 during localized and systemis infections. Our results let suggest that (i) IL-3 improved the local antiviral defence mechanisms by recruiting pDCs from the circulation; (ii) IL-3 functions as a predictive disease marker for viral reactivation in sepsis; (iii) IL-3 orchestrates intestinal inflammation during IBDs; (iv) IL-3 helped to detect septic conditions using the ECLipse assay. Altogether, IL-3 has the potential to act as diagnostic and therapeutic target in localized and systemic inflammatory conditions.

Publications

• Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections. Nature Communications, 12(1).
  Bénard, Alan; Jacobsen, Anne; Brunner, Maximilian; Krautz, Christian; Klösch, Bettina; Swierzy, Izabela; Naschberger, Elisabeth; Podolska, Malgorzata J.; Kouhestani, Dina; David, Paul; Birkholz, Torsten; Castellanos, Ixchel; Trufa, Denis; Sirbu, Horia; Vetter, Marcel; Kremer, Andreas E.; Hildner, Kai; Hecker, Andreas; Edinger, Fabian ... & Weber, Georg F.
  
• Electrochemiluminescence in paired signal electrode (ECLipse) enables modular and scalable biosensing. Science Advances, 8(38).
  Cho, Young Kwan; Kim, Hyunho; Bénard, Alan; Woo, Hyun-Kyung; Czubayko, Franziska; David, Paul; Hansen, Frederik J.; Lee, Jong Ik; Park, Jay Hoon; Schneck, Emmanuel; Weber, Georg F.; Shin, Ik-Soo & Lee, Hakho
  
• IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils. Cell Reports, 42(6), 112637.
  Bénard, Alan; Mittelstädt, Anke; Klösch, Bettina; Glanz, Karolina; Müller, Jan; Schoen, Janina; Nüse, Björn; Brunner, Maximilian; Naschberger, Elisabeth; Stürzl, Michael; Mattner, Jochen; Muñoz, Luis E.; Sohn, Kai; Grützmann, Robert & Weber, Georg F.
  
• Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming. Frontiers in Immunology, 14.
  Bénard, Alan; Hansen, Frederik J.; Uhle, Florian; Klösch, Bettina; Czubayko, Franziska; Mittelstädt, Anke; Jacobsen, Anne; David, Paul; Podolska, Malgorzata J.; Anthuber, Anna; Swierzy, Izabela; Schaack, Dominik; Mühl-Zürbes, Petra; Steinkasserer, Alexander; Weyand, Michael; Weigand, Markus A.; Brenner, Thorsten; Krautz, Christian; Grützmann, Robert & Weber, Georg F.