Quality control at the protein entry gate of mitochondria (B11)

• Subject Area: Biochemistry ; Cell Biology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

The translocase of the outer mitochondrial membrane (TOM complex) imports about 1000 different proteins into mitochondria. Three different pathways remove translocation-stalled precursor proteins from the TOM channel. We will investigate the molecular cooperation between these pathways and define how their functions are coordinated at the TOM complex. We will determine substrate-specificity and interactions of the quality control components that govern mitochondrial protein import.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Co-Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Thomas Becker