Biosynthesis investigations of an antifungal peptide

• Applicant: Professor Dr. Roderich D. Süßmuth
• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 446001085

The gene cluster of a non-ribosomally synthesized peptide from a bacterium of the phylum proteobacteria is investigated by gene inactivation mutagenesis and in-vitro reconstitution of the biosynthesis. Additionally, a synthetic approach to the peptide will be elaborated, which will concomitantly provide access to enzyme substrates. With the investigation of the gene cluster we pursue to obtain insights into a new type of non-ribosomal peptide synthesis as well as preliminary insights into structure-activity-relations.

• DFG Programme: Research Grants
• International Connection: France
• Cooperation Partner: Privatdozent Dr. Stephane Cociancich