Towards a novel small animal quantitative perfusion MRI reference standard

• Applicant: Dr. Philipp Backhaus
• Subject Area: Medical Physics, Biomedical Technology ; Nuclear Medicine, Radiotherapy, Radiobiology
• Term: from 2020 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 446292030

• Final Report Year: 2023

No abstract available

Publications

• Translational imaging of the fibroblast activation protein (FAP) using the new ligand [68Ga]Ga-OncoFAP-DOTAGA. European Journal of Nuclear Medicine and Molecular Imaging, 49(6), 1822-1832.
  Backhaus, P.; Gierse, F.; Burg, M. C.; Büther, F.; Asmus, I.; Dorten, P.; Cufe, J.; Roll, W.; Neri, D.; Cazzamalli, S.; Millul, J.; Mock, J.; Galbiati, A.; Zana, A.; Schäfers, K. P.; Hermann, S.; Weckesser, M.; Tio, J.; Wagner, S. ... & Schäfers, M.
  
• EMIM 2022. Vortrag. Comparison of Image & Extracorporeal derived Arterial Input Functions (AIF) for quantitative Pharmacokinetic Modeling in Mice using the Extended Tofts Model (ETM).
  F. Gierse, J. Cufe, B. Maus, M. Claesener, S. Hermann, K. P. Schäfers, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• ESMRMB 2022. Poster. Hybrid PET/MRI validation of arterial input functions after dual injection of MR contrast agents and their radioactive analogs in mice using an extracorporeal circulation approach at 9.4T BioSpec high-field MRI.
  F. Gierse, J. Cufe, B. Maus, M. Claesener, S. Hermann, K. P. Schäfers, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• ISMRM 2022. Poster. Comparison of image and extracorporeally derived arterial input functions (AIF) for DCE-MRI – evaluation with different vascular access ways and simultaneous radiotracer recordings.
  F. Gierse, J. Cufe, B. Maus, M. Claesener, S. Hermann, K. P. Schäfers, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• ISMRM perfusion workshop 2022. Poster. Comparison of Image & Extracorporeal Derived Arterial Input Functions (AIF) for Quantitative DCE-MRI in Mice Using a Multimodal Cross-Validation Approach.
  F. Gierse, J. Cufe, B. Maus, M. Claesener, S. Hermann, K. P. Schäfers, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• Nuklearmedizin 2022. Vortrag. Evaluation of different vascular access ways in an extracorporeal circulation model for quantitative determination of dual PET/MRI arterial input functions in mice.
  F. Gierse, J. Cufe, B. Maus, M. Claesener, S. Hermann, K. P. Schäfers, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• EMIM 2023. Poster. Posterpreis Kategorie “New Methods, Cross-Modal Neuroimaging & Validation”. Accurate Pharmacokinetic Modeling Using an Extracorporeal Circulation by Shunting the Carotid Artery for AIF Determination in Mice – A Multimodal Step-by-Step Validation Approach.
  F. Gierse, J. Cufe, B. Maus, K. Kronenberg, M. Claesener, S. Hermann, K. P. Schäfers, U. Karst, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• ISMRM 2023. Poster. Stepwise validation of Perfusion MRI Kinetic Modeling using an Extracorporeal circulation for AIF determination in Mice.
  F. Gierse, J. Cufe, B. Maus, K. Kronenberg, M. Claesener, S. Hermann, K. P. Schäfers, U. Karst, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus
  
• Nuklearmedizin 2023. Vortrag. Stepwise validation of Perfusion MRI Kinetic Modeling using an Extracorporeal Circulation for AIF determination in Mice.
  F. Gierse, J. Cufe, B. Maus, K. Kronenberg, M. Claesener, S. Hermann, K. P. Schäfers, U. Karst, C. Faber, M. A. Schäfers, F. Büther & P. Backhaus