FOR 5228:  Membrane trafficking processes underlying presynaptic proteostasis

• Subject Area: Medicine ; Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 447288260

No abstract available

• DFG Programme: Research Units
• International Connection: Israel

Projects

• Amphisome biogenesis couples synaptic autophagy to local protein synthesis (Applicants Andres-Alonso, Maria ;  Gundelfinger, Eckart D. ;  Kreutz, Michael R. )
• Autophagic regulation of synapse formation in the Drosophila brain (Applicant Hiesinger, Peter Robin )
• Coordination Funds (Applicant Kreutz, Michael R. )
• Interdependencies of autophagy, protein synthesis, aging, activity and synaptic viability. (Applicants Dieterich, Daniela C. ;  Ziv, Ph.D., Noam )
• Maintaining presynaptic function in dopaminergic synapses (Applicants Gundelfinger, Eckart D. ;  Rosenmund, Christian )
• Molecular and Functional Integration of Neuronal Autophagy and Presynaptic Remodeling (Applicants Maglione, Ph.D., Marta ;  Sigrist, Stephan J. )
• Molecular mechanism and function of neuronal autophagy (Applicants Haucke, Ph.D., Volker ;  Liu, Fan )
• NPY-mediated autophagy and the adaptation of hippocampal circuits to stress (Applicants Albrecht, Anne ;  Stork, Oliver )
• Regulation of neuron-specific UPS and autophagy with aging (Applicants Eickholt, Britta ;  Kirstein, Janine )
• The Role of Chaperone-mediated Endolysosomal Degradation (CMED) in Presynaptic Proteostasis (Applicants Grochowska, Ph.D., Katarzyna ;  Rosenmund, Christian ;  Ziv, Ph.D., Noam )
• The role of Myosin VI in regulating degradative organelle positioning and secretion in axons (Applicant Mikhaylova, Marina )
• The role of neuronal β₂-adrenergic receptors in the regulation of non-canonical autophagy in vivo (Applicant Karpova, Ph.D., Anna )

• Spokesperson: Professor Dr. Michael R. Kreutz