Orexinergic modulation of neural resource (A07)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

In this project we will explore the potential of orexinergic neuromodulation and the wakefulness promoting system to mobilise neural resources by stimulating prefrontal cortex-to-hippocampus signalling and to build up resources through increasing neural plasticity in the hippocampus. We will probe these functions and underlying physiological processes with behavioural, pharmacological and viral interventions at the micro-, local and long-range circuit level. Closely interconnected to other CRC projects we expect to obtain insights into neuronal circuits and cellular mechanism supporting battling cognitive decline.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professorin Dr. Anne Albrecht; Professor Dr. Oliver Stork