Synaptic density, MTL circuit function and microvascular plasticity in aging and SuperAging (B04)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

Based on results in the first funding period, we aim to understand the contributions of synaptic and microvascular integrity to entorhinal-hippocampal network function in old age and whether we can induce microvascular plasticity and MTL-network changes by targeted focussed ultrasound in the entorhinal cortex to promote cognitive reserve. By employing innovative PET and MR imaging techniques, our study will lay the ground for the potential use of targeted focussed ultrasound as an intervention to unlock cognitive reserve in MTL-related pathologies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Henryk Barthel; Professorin Esther Kühn, Ph.D., until 12/2024; Professorin Dr. Anne Maass; Professorin Dr. Stefanie Schreiber