SFB 1506:  Aging at Interfaces

• Subject Area: Medicine ; Biology
• Term: since 2022
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

No abstract available

• DFG Programme: Collaborative Research Centres
• International Connection: Israel

Current projects

• A01 - Synaptic aging as a “physiological synaptopathy” (Project Heads Böckers, Tobias ;  Catanese, Ph.D., Alberto )
• A02 - Activity-dependent neuronal Ca2+ signaling and its role in aging and Parkinson’s disease (Project Head Liss, Birgit )
• A03 - Interaction between protein aggregation, age and exposure time to misfolded proteins (Project Head Danzer, Karin )
• A04 - The effects of aging on glial cells of the brain: implications for physiological functions (Project Head Dimou, Leda )
• A05 - Notch/NF-KB crosstalk at the aging synapse: Role of inflammaging on cognitive decline (Project Heads Baumann, Bernd ;  Oswald, Franz )
• A06 - Loss of translational accuracy in aging and aging-associated disease (Project Head Iben, Sebastian )
• B01 - Mechanisms of aging and rejuvenation of human hematopoietic stem cells (Project Heads Geiger, Hartmut ;  Mulaw, Ph.D., Medhanie )
• B03 - Aging at the interface of DNA damage and inflammatory response: Specific impact of the sex (Project Heads Rall-Scharpf, Melanie ;  Wiesmüller, Elisabeth Maria )
• B04 - Clearance of Senescent Cells by Rejuvenation of the Aged Immune System (Project Heads Krizhanovsky, Ph.D., Valery ;  Schirmbeck, Reinhold )
• B05 - The role of autoantibody diversity in physiological homeostasis during aging (Project Head Jumaa, Hassan )
• B06 - Computational Modeling of Hematopoietic Stem Cell Aging (Project Heads Geiger, Hartmut ;  Kestler, Hans A. )
• C01 - Interplay between HIV and amyloids in human aging (Project Head Kirchhoff, Frank )
• C02 - Fibroblast Senescence Drives Connective Tissue and Organ Aging (Project Head Scharffetter-Kochanek, Karin )
• C03 - Aging at the Interface of HIV and Transposable Elements (Project Head Sauter, Daniel )
• C04 - The interface of regeneration and aging: zebrafish regeneration requires elevated anti-aging mechanisms (Project Head Weidinger, Gilbert )
• C05 - Modulation of the macrophage/adipocyte interface in age-related insulin resistance by the Glucocorticoid Receptor (Project Heads Gebhardt, Christof ;  Tuckermann, Jan )
• C06 - Epigenetic clocks, blood-based biomarkers and functional parameters for the estimation of biological age (Project Heads Dallmeier, Ph.D., Dhayana ;  Rothenbacher, Dietrich ;  Wagner, Wolfgang )
• Z01 - Administrative Core: Central Tasks of the CRC (Project Head Geiger, Hartmut )
• Z02 - Tissues and animals for aging research – an interdisciplinary approach (Project Heads Dallmeier, Ph.D., Dhayana ;  Denkinger, Michael ;  Geiger, Hartmut ;  Liebold, Andreas ;  Rothenbacher, Dietrich ;  Scharffetter-Kochanek, Karin ;  Schrezenmeier, Hubert )

• Applicant Institution: Universität Ulm
• Spokesperson: Professor Dr. Hartmut Geiger