Project Details
Projekt
Targeting the ADPR-binding macrodomain associated de-MARylation/ dePARylation enzyme activity as novel approach towards viral replication inhibitors (A18)
Subject Area
Biochemistry
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 335447717
The project investigates the interaction of the SARS-CoV-2 macrodomain (Mac1) with the host antiviral response. It uses newly identified, specific small-molecule inhibitors. The lead (pro)drug will be optimised and its pharmacokinetic, pharmacodynamic and toxicological properties evaluated in vivo. The inhibitor’s activity against related viral macrodomains will be assessed. AAV-delivered anti-Mac1 intrabodies will be developed as diagnostic and inhibitory tools. Host interaction partners of Mac1 will be identified to clarify the molecular basis of Mac1-mediated host response suppression.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Heads
Dr. Ralf Fliegert; Professor Dr. Chris Meier; Dr. Susanne Pfefferle
