Project Details
Projekt
Metabolic targeting of bacteria through complex carbohydrates (A04)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
We aim to develop reliable diagnostic tools that enable the differentiation between sterile inflammation and bacterial infection. Therefore, we will design radiolabelled specific imaging probes based on oligosaccharides which are selectively taken up by bacteria. These tracers will be tested in vitro as well as in vivo with gram-positive and gram-negative bacterial strains providing us information on the possible applications in clinical practice. In mouse models we will follow bacterial infection non-invasively over time and analyse the interaction of bacteria with immune cells using novel tracers developed in this and other projects in this CRC.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Dr. Andreas Faust; Professor Dr. Ryan Gilmour; Dr. Silke Niemann
