Multiscale visualisation and analysis of innate immune cell migration at sites of hypoxic inflammation in vivo (B04)

• Subject Area: Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

The aim of this project is to generate new hypoxia reporters and reporter mice based on the oxygen-independent fluorescent protein UnaG, as well as metabolic reporters, which will be functionally tested and applied in preclinical models of myocardial infarction, kidney ischemia and intestinal infection. Using probabilistic machine learning on the imaging data generated, we will attempt to quantitatively analyse tissue hypoxia across multiple imaging scales with a particular focus on the explainability of our deep learning models to ensure trustworthy predictions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Friedemann Kiefer; Professor Dr. Benjamin Risse