Project Details
Projekt
Imaging of immune cell dynamics and host-pathogen interactions in gut-associated lymphoid tissue during Yersinia pseudotuberculosis infections (C07)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
In order to obtain a high spatio-temporal resolution of the infection process of the gut pathogen Yersinia pseudotuberculosis, we will image the recruitment and dynamics of immune cell populations and characterize Yersinia-targeted immune cells in infected lymphoid tissue of mice during the entire course of the infection. In this context, we will also analyse the role of platelets for neutrophil recruitment and address different neutrophil functions, including NET formation, and how they are manipulated by bacterial evasion mechanisms.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professorin Dr. Petra Dersch; Professor Dr. Jan Rossaint
