SFB 1526:  Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases

• Subject Area: Medicine
• Term: since 2022
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Autoantigen-specific T cells in pemphigoid diseases (Project Heads Scheffold, Alexander ;  Schmidt, Enno )
• A02 - Crosstalk between T cells and B cells in the differentiation of pathogenic plasma cells in pemphigoid diseases (Project Heads Heine, Guido ;  Manz, Rudolf )
• A03 - C5a receptor 1 activation as a regulator of autoantibody production in pemphigoid disease (Project Head Köhl, Jörg )
• A04 - Selective B cell depletion in pemphigoid diseases by bispecific antibodies (Project Heads Ludwig, Ralf Joachim ;  Peipp, Matthias )
• A05 - Role of the complement receptors 1 and 2 as drivers of autoantibody development and their potential as drug targets in pemphigoid diseases (Project Heads Hammers, Matthias Christoph ;  Verschoor, Ph.D., Admar )
• A06 - The role of neutrophils in the regulation of the adaptive immunity in pemphigoid diseases (Project Head Karsten, Christian )
• A07 - Cell subset-specific roles of FcRn in regulating autoantibody generation and activity in pemphigoid diseases (Project Head Nimmerjahn, Falk )
• A08 - Skin-infiltrating T and B cells in the pathogenesis of pemphigoid diseases (Project Heads Hutloff, Andreas ;  Ibrahim, Saleh M. )
• B01 - Site-specific inhibition of C5/C5a in pemphigoid diseases (Project Heads Ludwig, Ralf Joachim ;  Peipp, Matthias )
• B02 - G protein-coupled receptors orchestrating granulocytes in pemphigoid diseases (Project Heads Sadik, Christian David ;  Wettschureck, Nina )
• B04 - Kinase cascades in neutrophils as therapeutic target in pemphigoid diseases (Project Heads Bieber, Katja ;  Lux, Anja )
• B05 - Pathophysiology of granulocyte metabolism and its potential as therapeutic target in pemphigoid diseases (Project Heads Sadik, Christian David ;  Schilf, Paul )
• B06 - Targeting mitochondrial metabolism in pemphigoid diseases (Project Heads Hirose, Misa ;  Vaeth, Martin )
• B07 - Characterization and targeted modulation of the gut - skin axis in pemphigoid diseases (Project Heads Baines, John F. ;  Ibrahim, Saleh M. )
• B08 - Microbiota-specific T cell responses in pemphigoid diseases (Project Heads Bacher, Petra ;  Baines, John F. )
• B10 - Stromal regulation of inflammation in pemphigoid diseases (Project Head Hoffmann, Markus )
• INF - Information Infrastructure Project (Project Heads Busch, Hauke ;  Franke, Andre ;  Höppner, Ph.D., Marc )
• S01 - Clinical Research Support (Project Heads Becker, Mareike ;  Heine, Guido ;  Holtsche, Maike Marleen ;  Sadik, Christian David )
• S02 - Biostatistics, Systems Medicine, and Data Integration (Project Heads Fähnrich, Anke ;  Szymczak, Silke )
• S03 - Preclinical model systems of pemphigoid diseases (Project Heads Ludwig, Ralf Joachim ;  Murthy, Sripriya )
• Z - Central Tasks of the Collaborative Research Center (Project Heads Ludwig, Ralf Joachim ;  Sadik, Christian David )

• Applicant Institution: Universität zu Lübeck
• Spokespersons: Professor Dr. Ralf Joachim Ludwig, since 1/2025; Professor Dr. Christian David Sadik, from 7/2022 until 12/2024; Professor Dr. Detlef Zillikens, until 6/2022 (†)